Does endothelium agree with the concept of idiopathic hepatic vessel thrombosis?

摘要： <正> AIM:To investigate the major steps of thrombogenesisand to identify the differences in these steps betweenidiopathic patient group and control group.METHODS:Fibrinogenesis was studied by measuringthe activated factor Ⅶ,total and free levels of tissuefactor pathway inhibitor(TFPI).The fibrinolysis step wasinvestigated by determining the global fibrinolytic capa-city.The endothelial function was assessed by measuringthe levels of soluble adhesion molecules,namely solub-le intercellular adhesion molecule 1(sICAM-1),solublevascular cell adhesion molecule 1(sVCAM-1)and solubleE-selectin molecule.The exclusion criteria from"idiopat-hic"patient group were abdominal surgery,pregnancy,use of oral contraceptives,anti-phospholipid syndrome,Behcet's disease,cancer,myeloproliferative diseases.The congenital factors like mutations of factor-V Lei-den and prothrombin,deficiencies of proteins C and S,antithrombin,hyperhomocysteinemia and hyperfibrino-genemia were ruled out.The total number of patientswas reduced from 96 to 9(7 with portal vein thrombosis,2 Budd Chiari syndrome)by exclusion criteria.RESULTS:The levels of adhesion molecules sICAM-1,sVCAM-1,free TFPI levels and global fibrinolytic capacitywere significantly different(P<0.05)in the patient groupindicating an endothelial dysfunction and a lower fibri-nolytic activity.CONCLUSION:These results show that this patientgroup should be tested by means of endothelial dysfunc- tion and managed differently. （共5頁(yè)）