SUMMATION OF ABSOLUTE VALUE TEST FOR MULTIPLE OUTCOME COMPARISON WITH MODERATE EFFECT

摘要： In biomedical research,in order to evaluate the effect of a drug,investigators often need to compare the differences between one treatment group and another one by using multiple outcomes.The rank-sum tests can handle the case where the outcome differences between two groups are in the same direction.If they are not,MAX can handle it and is very useful when one/some of the differences is/are relatively larger than the others.When the individual outcome difference between two groups is moderate,a new method,summation of the absolute value of rank-based test for each outcome,is proposed in this work.Power comparison with the existing methods based on simulation studies and a real example show that the proposed test is a robust test,and works well when the difference for each outcome is moderate.The authors also derive some theoretical results for comparing the power between MAX and the the proposed method. （共8頁(yè)）