Riskfactorsforsmallbowelangioectasia:Theimpactofvisceralfataccumulation

摘要： AIM:Toinvestigatevisceralfataccumulationinassociationwiththeriskofsmallbowelangioectasia.METHODS:Weretrospectivelyinvestigated198consecutivepatientswhounderwentbothcapsuleendoscopyandCTforinvestigationofobscuregastrointestinalbleeding(OGIB)fromJanuary2009toSeptember2013.Thevisceralfatarea(VFA)andsubcutaneousfatareaweremeasuredbyCT,andinformationoncomorbidities,bodymassindex,andmedicationswasobtainedfromtheirmedicalrecords.Logisticregressionanalysiswasusedtoevaluateassociations.RESULTS:Capsuleendoscopyrevealedsmallbowelangioectasiain18/198(9.1%)patientswithOGIB.Comparedtopatientswithoutsmallbowelangioectasia,thosewithsmallbowelangioectasiahadasignificantlyhigherVFA(96±76.0cm2vs63.4±51.5cm2,P=0.016)andahigherprevalenceoflivercirrhosis(61%vs22%,P<0.001).Theproportionofpatientswithchronicrenalfailurewashigherinpatientswithsmallbowelangioectasia(22%vs9%,P=0.11).Therewerenosignificantdifferencesinsubcutaneousfatareaorwaistcircumference.TheprevalenceofsmallbowelangioectasiaprogressivelyincreasedaccordingtotheVFA.MultivariateanalysisshowedthattheVFA[oddratio(OR)foreach10-cm2increment=1.1;[95%confidenceinterval(CI):1.02-1.19;P=0.021]andlivercirrhosis(OR=6.1,95%CI:2.2-18.5;P<0.001)weresignificantriskfactorsforsmallbowelangioectasia.CONCLUSION:VFAispositivelyassociatedwiththeprevalenceofsmallbowelangioectasia,forwhichVFAandlivercirrhosisareindependentriskfactorsinpatientswithOGIB. （共6頁）