Microwaveablationofhepatocellularcarcinoma
WorldJournalofHepatology
頁數(shù): 12 2015-11-08
摘要: Althoughsurgicalresectionisstilltheoptimaltreatmentoptionforearly-stagehepatocellularcarcinoma(HCC)inpatientswithwellcompensatedcirrhosis,thermalablationtechniquesprovideavalidnonsurgicaltreatmentalternative,thankstotheirminimalinvasiveness,excellenttolerabilityandsafetyprofile,provenefficacyinlocaldiseasecontrol,virtuallyunlimitedrepeatabilityandcost-effectiveness.Differentenergysourcesarecurrentlyemployedinclinicsasphysicalagentsforpercutaneousorintra-surgicalthermalablationofHCCnodules.Amongthem,radiofrequency(RF)currentsarethemostused,whilemicrowaveablations(MWA)arebecomingincreasinglypopular.Startingfromthe90s,RFablation(RFA)rapidlybecamethestandardofcareinablation,especiallyinthetreatmentofsmallHCCnodules;however,RFAexhibitssubstantialperformancelimitationsinthetreatmentoflargelesionsand/ortumorslocatednearmajorheatsinks.MWA,firstintroducedintheFarEasternclinicalpracticeinthe80s,showingpromisingresultsbutalsoseverelimitationsinthecontrollabilityoftheemittedfieldandinthehighamountofpoweremployedfortheablationoflargetumors,resultinginapoorcoagulativeperformanceandarelativelyhighcomplicationrate,nowadaysshowsbetterresultsbothintermsoftreatmentcontrollabilityandofoverallcoagulativeperformance,thankstotheimprovementoftechnology.InthisreviewweprovideanextensiveanddetailedoverviewofthekeyphysicalandtechnicalaspectsofMWAandofthecurrentlyavailablesystems,andwewanttodiscussthemostrelevantpublisheddataonMWAtreatmentsofHCCnodulesinregardtoclinicalresultsandtothetypeandrateofcomplications,bothinabsolutetermsandincomparisonwithRFA. (共12頁)